Table 1 Major studies on transcatheter embolisation of uterine leiomyoma
Author | Number of patients | Follow-up time | Symptoms | Improvement of initial symptoms | Side effects, complications |
|---|---|---|---|---|---|
Worthington-Kirsch et al. (1998) [49] | 53 | 3 months | Bleeding disorder (100%), pelvic pain (58%), anaemia (41%) | Improvement of bleeding disorder and anaemia (88%), of pelvic pain (94%), average volume reduction of myoma (46%) | Postembolisation syndrome (24 patients); nausea/vomiting (22 patients); pelvic pain (20 patients) |
Hutchins et al. (1999) [18] | 305 | 12 months | Menorrhagia, pelvic pain | Average volume reduction of the uterus (48%), improvement of menorrhagia, pelvic pain in 92% after 12 months, hysterectomy in six cases, in five cases myomectomy | No severe complications |
Goodwin et al. (1999) [13] | 60 | 16.3 months | Bleeding disorder, pelvic pain | Average volume reduction of uterus and myoma for 42.8 and 48.8%; improvement of clinical symptoms in 81% | Postembolisationsyndrome in six cases; one case of amenorrhoea; one case of protracted infection with subsequent hysterectomy |
Vashisht et al. (2000) [40] | 21 | 12 months | Menorrhagia (66%), abdominal tension (33%) | Improvement of bleeding disorders in 9/13 cases, improvement of abdominal tension in 2/7 cases, 1 pregnancy | One case of lethal overwhelming septicimia |
Ravina et al. (2000) [32] | 286 | 6 months | Bleeding disorders, pelvic pressure | Reduction of myoma volume of 60%, significant improvement of uterine bleeding in 80%, 18 pregnancies | No severe complications |
Pelage et al. (2000) [28] | 80 | 24 months | Uterine bleeding, pelvic pain | Improvement of menorrhagia in 90%, three pregnancies | Septical necrosis of myoma requiring hysterectomy in one patient; permanent amenorrhoea in four patients |
Siskin et al. (2000) [28] | 49 | 3 months | Bleeding disorder, anaemia, abdominal tension | Average reduction of uterine volume of 47.5%, general improvement of symptoms in 88% of patients | Pelvic pain, nausea/vomiting |
Brunereau et al. (2001) [10] | 58 | 3–24 months | Bleeding disorder, pressure, pelvic pain | After 1 year 2/27 patients with no change, 3/27 improvement, 22/27 reduction of uterine size in 26% and of myoma in 51% without symptoms | In three cases fever, headaches, nausea/vomiting |
Andersen et al. (2001) [2] | 62 | 12 months | Menorrhagia, pain | In two cases no change, reduced uterine bleeding in 21 patients (96%), reduction of bleeding in 21 patients (70%), less pelvic pain in 18 patients (61%), less pelvic pressure, reduction of uterine volume of 68%, one pregnancy | Endometritis in one patient, allergies in four patients, haematoma due to vascular puncture in two patients |