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Table 1 Major studies on transcatheter embolisation of uterine leiomyoma

From: Embolisation of uterine arteries or laparascopic uterine artery ligation as possible treatment of uterine leiomyoma

Author Number of patients Follow-up time Symptoms Improvement of initial symptoms Side effects, complications
Worthington-Kirsch et al. (1998) [49] 53 3 months Bleeding disorder (100%), pelvic pain (58%), anaemia (41%) Improvement of bleeding disorder and anaemia (88%), of pelvic pain (94%), average volume reduction of myoma (46%) Postembolisation syndrome (24 patients); nausea/vomiting (22 patients); pelvic pain (20 patients)
Hutchins et al. (1999) [18] 305 12 months Menorrhagia, pelvic pain Average volume reduction of the uterus (48%), improvement of menorrhagia, pelvic pain in 92% after 12 months, hysterectomy in six cases, in five cases myomectomy No severe complications
Goodwin et al. (1999) [13] 60 16.3 months Bleeding disorder, pelvic pain Average volume reduction of uterus and myoma for 42.8 and 48.8%; improvement of clinical symptoms in 81% Postembolisationsyndrome in six cases; one case of amenorrhoea; one case of protracted infection with subsequent hysterectomy
Vashisht et al. (2000) [40] 21 12 months Menorrhagia (66%), abdominal tension (33%) Improvement of bleeding disorders in 9/13 cases, improvement of abdominal tension in 2/7 cases, 1 pregnancy One case of lethal overwhelming septicimia
Ravina et al. (2000) [32] 286 6 months Bleeding disorders, pelvic pressure Reduction of myoma volume of 60%, significant improvement of uterine bleeding in 80%, 18 pregnancies No severe complications
Pelage et al. (2000) [28] 80 24 months Uterine bleeding, pelvic pain Improvement of menorrhagia in 90%, three pregnancies Septical necrosis of myoma requiring hysterectomy in one patient; permanent amenorrhoea in four patients
Siskin et al. (2000) [28] 49 3 months Bleeding disorder, anaemia, abdominal tension Average reduction of uterine volume of 47.5%, general improvement of symptoms in 88% of patients Pelvic pain, nausea/vomiting
Brunereau et al. (2001) [10] 58 3–24 months Bleeding disorder, pressure, pelvic pain After 1 year 2/27 patients with no change, 3/27 improvement, 22/27 reduction of uterine size in 26% and of myoma in 51% without symptoms In three cases fever, headaches, nausea/vomiting
Andersen et al. (2001) [2] 62 12 months Menorrhagia, pain In two cases no change, reduced uterine bleeding in 21 patients (96%), reduction of bleeding in 21 patients (70%), less pelvic pain in 18 patients (61%), less pelvic pressure, reduction of uterine volume of 68%, one pregnancy Endometritis in one patient, allergies in four patients, haematoma due to vascular puncture in two patients
  1. Dt. Ärzteblatt 99 (2002), No. 26, A 1829