Laparoscopic ovarian drilling (LOD) in patients with polycystic ovary syndrome (PCOS): an alternative approach to medical treatment?

Table 2 Randomised controlled trials in laparoscopic ovarian drilling (no abstracts)

Author	Trial design	No. of patients	Ovulation rate	Pregnancy rate
Abdel Gadir [19]	LOD	29	71.4%	52.1%
	HMG	30	70.6%	38.3%
	FSH	28	66.7%
Balen and Jacobs [28]	Unilateral	4	75%	0%
Balen and Jacobs [28]	Bilateral LOD	6	33%	0%
Farquhar et al. [39]	LOD	28	54%	28.5%
Farquhar et al. [39]	Three cycles HMG/FSH	19	81% per cycle	21.2%
Münstermann and Kleinstein [33]	LOD	10	70%	50%
Münstermann and Kleinstein [33]	6 months GnRH analogues followed by three cycles low-dose FSH	8	67% (FSH stimulat.)	63%
Takeuchi et al. [40]	Harmonic scalpel laser	17	94%	77%
Takeuchi et al. [40]	Nd:YAG laser	17	94%	60%
Bayram et al. [43]	Electrocautery	83	70%	34%
Bayram et al. [43]	Six cycles FSH	85	n.a.	67%
Palomba et al. [45]	Metformin	54	54.8%	18.6%
Palomba et al. [45]	LOD	55	53.3% per cycle	13.4% per cycle