Cervical ectopic pregnancy: surgical or medical treatment?
© Springer-Verlag Berlin / Heidelberg 2006
Received: 22 January 2006
Accepted: 8 June 2006
Published: 4 August 2006
Cervical pregnancies are one of the rarest forms of ectopic gestations. The incidence of cervical ectopic pregnancies ranges between 1 in 1,000 to 95,000 gestations (Parente et al., Obstet Gynecol 62:79–82, 1983). Prior surgical trauma, including dilatation and curettage of the cervix, has been identified as one of the leading risk factors (Pisarska et al., Lancet 351:1115–1120, 1998; Yankowitz et al., Obstet Gynecol Surv 45:405–414, 1990). Cervical ectopic pregnancies are especially feared due to their associated life-threatening hemorrhage. Therefore, massive blood transfusions and emergency hysterectomy have often been required previously. Nevertheless, general guidelines for clinical management are lacking. In case reports medical and surgical treatment modalities are described. Overall, conservative management of an asymptomatic cervical ectopic pregnancy using methotrexate or potassium chloride seems to be superior to surgical intervention. The treatment of choice in patients suffering from symptomatic cervical ectopic pregnancy is still under discussion. In the case reported here, a combination of surgical and medical treatment conserving the patient’s childbearing capacity was successfully implemented. However, severe hemorrhage occurred and consecutive blood transfusions were urgently necessary. Emergency hysterectomy could be avoided.
Ectopic pregnancies (EP) are still a major problem, with more than 10,000 cases diagnosed annually in the UK . The incidence of EP ranges between 1 and 2% of all gestations. Cervical pregnancy is one of the rarest ectopic gestations that accounts for <1% of extrauterine pregnancies . Cervical ectopic pregnancies (CEP) are especially feared due to their associated life-threatening transvaginal hemorrhage associated with the high risk of emergency hysterectomy and massive blood transfusions. In the past, hysterectomy was often the only choice available due to extensive and uncontrollable hemorrhage . Nowadays, using high-resolution transvaginal sonography (TVS), the accuracy of the diagnosis of “cervical ectopic pregnancy” has significantly improved. Currently over 90% of EP can be visualized on TVS . This means that EP can be diagnosed in an earlier stage when the woman is still asymptomatic. Therefore, not surgery but conservative medical treatment using methotrexate (MTX) or potassium chloride (KCl) might be the more appropriate treatment modality. Still, there is no treatment of choice; in particular, for the management of more advanced CEP no “gold standard” has been established. We report a case of a nulliparous patient with CEP at 12 and 3/7 weeks gestation. A combination of conservative measures including surgical and medical procedures was successfully implemented. This case report discusses the diagnostic approach and therapeutic options available for the management of CEP in hemodynamically stable patients.
Now, 2 years after therapy for CEP, this patient is pregnant again with an intrauterine singleton gestation.
CEP is a rare obstetrical complication. CEP carries the considerable risk of maternal mortality or serious morbidity due to severe hemorrhage [7, 8]. In the last decade, the improved accuracy of TVS led to the favorable fact that many cases of CEP are diagnosed preoperatively. It is still a central point in atypical ectopic pregnancies: for their safe therapeutic treatment an early diagnosis in asymptomatic women is necessary! The identification of CEP is mostly based upon a high degree of clinical suspicion confirmed by ultrasound examination [3, 9]. Sonographic findings include an empty uterus and a gestation filling the cervical canal (Fig. 1) . The differential diagnosis of CEP is a prior intrauterine gestational sac in the process of being expelled from the uterine cavity. The main difference between these clinical situations is that in CEP the internal os of the cervical canal is closed, whereas in cervical abortion it is dilated. If any doubt remains, magnetic resonance imaging is recommended .
The essential early diagnosis of CEP allows for careful planning of more conservative procedures in those patients who desire preservation of childbearing capacity . For conservation of the uterus various therapeutic options are described including surgical ligation of blood vessels or artery embolization [9, 12–14], use of a Foley catheter to tamponade the endocervix after dilatation and curettage [13, 15, 16], cervical cerclage [15, 17], and medical management with cytotoxic agents [11, 14, 18–22]. A review of the literature shows, although mainly consisting of case reports, that the present treatment standard in asymptomatic CEP is MTX combined with intra-amniotic feticide in the case of a viable pregnancy [23, 24]. Controversy remains about the criteria for a safe and successful medical or, on the other hand, surgical treatment. Many attempts are described to determine special risk factors predictive of the success rate of an either conservative or surgical procedure. The clinical conditions for the conservative medical approach were recently outlined in a noteworthy report by Ushakov et al. .
Risk factors for unsuccessful conservative medical management have been identified [25–27]. First, a serum β-HCG level of more than 10,000 mlU/ml and cardiac activity were found to be associated with higher treatment failure of MTX . Second, Hung et al. have added two more prognostic factors indicating an elevated risk of treatment failure of MTX: ≥9 weeks gestation and CRL >10 mm [26, 27]. On the other hand, a review of the current literature reveals that there are some cases of advanced CEP with poor prognostic factors but an excellent clinical outcome after conservative medical treatment [9, 11, 22, 28, 29].
This patient was symptomatic presenting with lower abdominal pain and moderate vaginal bleedings. The prognostic factors for successful medical treatment were unfavorable. Therefore, we elected to perform a conservative surgical procedure. The conservative surgical intervention using dilatation and curettage of the cervix led to significant vaginal bleedings. The availability and urgent use of massive blood transfusions was life-saving. Even though the childbearing capacity of this patient could be preserved, uncertainty remained about whether a more conservative primary medical management would have been more secure for the patient. In agreement with Mitra et al., we believe that also viable CEP of more than 10 weeks gestation can be treated successfully with medical therapy . Moreover, in fetuses with cardiac activity it seems that intra-amniotic and/or intrafetal injection of MTX or KCl is usually necessary to reliably stop fetal cardiac activity and induce pregnancy resorption. Still, the most effective administration route of cytotoxic agents remains unclear. Frates et al. described the use of intrafetal or intra-amniotic KCl as a single agent in early CEP . We agree with Hidalgo et al. that one weakness of MTX treatment is the inability to predict the occurrence of massive bleedings .
Generally, the need for primary surgical treatment in CEP increases with advancing gestational age [7, 8, 11, 30]. In this clinical situation significant and life-threatening vaginal hemorrhage remains the major concern. For the safe clinical management of advanced CEP some points must be outlined: in asymptomatic patients presenting with CEP primary conservative medical management using MTX or KCl is always a possible treatment option. At any time when treating a patient with CEP, a considerable amount of packed red blood cells must be held in reserve. Furthermore, local or systemic measures ensuring hemostasis such as cervical tamponade or blockade using a Foley catheter, percutaneous embolization of pelvic vessels, or surgical ligation of cervical branches of uterine arteries must be available immediately. Urgent laparotomy must be possible at any time.
In summary, there are no guidelines available for clinicians. Therefore, each case of CEP must be managed individually taking the presented management modalities carefully into account.
- “Why mothers die,” triennial report 2000–2002. Confidential enquiry into maternal deaths, UKGoogle Scholar
- Parente JT, Ou CS, Levi J, Legatt E (1983) Cervical pregnancy analysis: a review and report of five cases. Obstet Gynecol 62:79–82PubMedGoogle Scholar
- Cunningham FG, Gant NF, Leveno KJ, Gilstrap LC III, Hauth JC, Wenstrom KD (2001) Ectopic pregnancy, chapter 24. In: Williams obstetrics, 21st edn. McGraw-Hill, New York, pp 884–910Google Scholar
- Condous G, Okaro E, Khalid A, Lu C, Van Huffel S, Timmerman D, Bourne T (2005) The accuracy of transvaginal ultrasonography for the diagnosis of ectopic pregnancy prior to surgery. Hum Reprod 20:1404–1409PubMedView ArticleGoogle Scholar
- Pisarska MD, Carson SA, Buster JE (1998) Ectopic pregnancy. Lancet 351:1115–1120PubMedView ArticleGoogle Scholar
- Yankowitz J, Leake J, Huggins G, Gazaway P, Gates E (1990) Cervical ectopic pregnancy: review of the literature and report of a case treated by single-dose methotrexate therapy. Obstet Gynecol Surv 45:405–414PubMedView ArticleGoogle Scholar
- Sivaligam N, Mak FK (2000) Delayed diagnosis of cervical pregnancy: management options. Singapore Med J 41:599–601Google Scholar
- Tuncer R, Uygur D, Kis S, Kayin S, Bebitoglu I, Erkaya S (2001) Inevitable hysterectomy despite conservative surgical management in advanced cervical pregnancy: a case report. Eur J Obstet Gynecol Reprod Biol 100:102–104PubMedView ArticleGoogle Scholar
- Frates MC, Benson CB, Doubilet PM et al (1994) Cervical ectopic pregnancy: results of conservative treatment. Radiology 191:773–775PubMedGoogle Scholar
- Bader-Armstrong B, Shah Y, Rubens D (1989) Use of ultrasound and magnetic resonance imaging in the diagnosis of cervical pregnancy. J Clin Ultrasound 17:283–286PubMedView ArticleGoogle Scholar
- Mitra AG, Harris-Owens M (2000) Conservative medical management of advanced cervical ectopic pregnancies. Obstet Gynecol Surv 55:385–389PubMedView ArticleGoogle Scholar
- Ratten GJ (1983) Cervical pregnancy treated by ligation of the descending branch of the uterine arteries: case report. Br J Obstet Gynaecol 90:367–371PubMedGoogle Scholar
- Saliken JC, Normore WJ, Pattinson HA, Wood S (1994) Embolization of the uterine arteries before termination of a 15-week cervical pregnancy. Can Assoc Radiol J 45:399–401PubMedGoogle Scholar
- Cosin JA, Bean M, Grow D, Wiczyk H (1997) The use of methotrexate and arterial embolization to avoid surgery in a case of cervical pregnancy. Fertil Steril 67:1169–1171PubMedView ArticleGoogle Scholar
- Bachus KE, Stone D, Suh B, Thickman D (1990) Conservative management of cervical pregnancy with subsequent fertility. Am J Obstet Gynecol 162:450–451PubMedGoogle Scholar
- Reginald PW, Reid JE, Paintin DB (1985) Control of bleeding in cervical pregnancy: two case reports. Br J Obstet Gynaecol 92:1199–1200PubMedGoogle Scholar
- Wharton KR, Gore B (1988) Cervical pregnancy managed by placement of a Shirodkar cerclage before evacuation. A case report. J Reprod Med 33:227–229PubMedGoogle Scholar
- Chew S, Anandakumar C (2001) Medical management of cervical pregnancy—a report of two cases. Singapore Med J 42:537–539PubMedGoogle Scholar
- Goldberg JM, Widrich T (2000) Successful management of a viable cervical pregnancy by single-dose methotrexate. J Womens Health Gend Based Med 9:43–45PubMedView ArticleGoogle Scholar
- Margolis K (2000) Cervical pregnancy treated with a single intravenous administration of methotrexate plus oral folinic acid. Aust N Z J Obstet Gynaecol 40:347–349PubMedGoogle Scholar
- Stovall TG, Ling FW, Smith WC, Felker R, Rasco BJ, Buster JE (1988) Successful nonsurgical treatment of cervical pregnancy with methotrexate. Fertil Steril 50:672–674PubMedGoogle Scholar
- Kung FT, Chang SY (1999) Efficacy of methotrexate treatment in viable and nonviable cervical pregnancies. Am J Obstet Gynecol 181:1438–1444PubMedView ArticleGoogle Scholar
- Ushakov FB, Elchalal U, Aceman PJ et al (1996) Cervical pregnancy: past and future. Obstet Gynecol Surv 52:45View ArticleGoogle Scholar
- Riethmuller D, Courtois L, Maillet R, Schaal JP (2003) Ectopic pregnancy management: cervical and abdominal pregnancies. J Gynecol Obstet Biol Reprod (Paris) 32:S101–S108Google Scholar
- Bai SW, Lee JS, Park JH, Kim JY, Jung KA, Kim SK, Park KH (2002) Failed methotrexate treatment of cervical pregnancy. Predictive factors. J Reprod Med 47:483–488PubMedGoogle Scholar
- Hung TH, Shau WY, Hsieh TT, Hsu JJ, Soong YK, Jeng CJ (1998) Prognostic factors for an unsatisfactory primary methotrexate treatment of cervical pregnancy: a quantitative review. Hum Reprod 13:2636–2642PubMedView ArticleGoogle Scholar
- Hidalgo LA, Penafiel J, Chedraui PA (2004) Management of cervical pregnancy: risk factors for failed systematic methotrexate. J Perinat Med 32:184–186PubMedView ArticleGoogle Scholar
- Brand E, Gibbs RS, Davidson SA (1993) Advanced cervical pregnancy treated with actinomycin-D. Br J Obstet Gynaecol 100:491–492PubMedGoogle Scholar
- Wolcott HD, Kaunitz AM, Nuss RC, Benrubi GE (1988) Successful pregnancy after previous conservative treatment of an advanced cervical pregnancy. Obstet Gynecol 71:1023–1025PubMedGoogle Scholar
- Honda T, Hasegawa M, Nakahori T, Maeda A et al (2005) Perinatal management of cervicoisthmic pregnancy. J Obstet Gynaecol Res 31:332–336PubMedView ArticleGoogle Scholar