- Case Report
- Open Access
Diagnosis and laparoscopic treatment of an unusual case of advanced extragenital endometriosis
© Springer-Verlag 2007
Received: 28 February 2007
Accepted: 14 June 2007
Published: 15 August 2007
Endometriosis is considered to be a benign gynaecological disorder, although several pathophysiological aspects of endometrial lesions resemble the behaviour of malignant tissue: similar to carcinomas, endometriotic cells are able to invade and destroy surrounding anatomical structures. Although the medical treatment of endometriotic lesions, including the use of GnRH analogues or gestagens, show temporary effectiveness and have been reported to cause a regression of disease, they rarely provide long-term relief of symptoms in advanced stages of endometriosis involving extragenital organs, such as the rectum or the urinary system. We here describe the diagnosis and minimally invasive surgical treatment of an unusually advanced case of endometriosis involving the rectosigmoid, the urinary bladder and the ureter, leading to secondary hydronephrosis and loss of renal function.
Endometriosis is characterised by the presence of endometrial tissue outside the uterine cavity and affects about 10% of the premenopausal female population . The disease, albeit considered to be a “benign” one, can resemble the biological behaviour of malignant tumours: endometriotic cells attach to and invade surrounding tissues, thereby, causing symptoms such as pelvic pain, dypareunia, dyschezia or infertility. Over the past few decades, a number of treatment strategies have been evaluated, although none have been proven to be entirely effective. Various medical treatments for endometriosis, such as non-steroidal antirheumatics, GnRH analogues or contraceptive pills do not appear to exhibit significant differences in their effectiveness and only last as long as the patients remain on their medication [2, 3]. In addition, antihormonal preparations such as GnRH analogues and/ or analgetic medications should not be prescribed on a long-term basis due to severe side-effects, including hot flushes, decrease of libido and bone mineral density, depression or impairment of renal function. Although radical surgical treatment for endometriosis remains an issue of constant debate, a number of studies, including randomised controlled trials, strongly suggest that excisional radical surgery is, indeed, highly effective in the treatment for endometriosis and warrants long-term curative effects regarding pelvic pain and subfertility [3–9]. However, some patients exhibit extensive involvement of extragenital tissues, such as the sigmoid and rectum, ureter and bladder, which confers a technical challenge for the surgeon, especially in a fertility-preserving treatment approach. We here describe the preoperative diagnosis and fertility-preserving laparoscopic treatment of an unusual case of extraordinary extensive extragenital disease involving the urinary bladder, the rectum and sigmoid colon and the ureter.
A 26-year old (gravida 0 para 0) female of Caucasian origin presented with a long-standing history of dysmenorrhea, pelvic pain, dyspareunia, severe dyschezia and primary subfertility at our department. In addition, haematuria and dysuria with intermittent episodes of frequency had developed within the past 3 months. Her medical history did not reveal any abnormalities and she was treated for common menstrual pain with non-steroidal antirheumatics and opioids over the recent few years. At presentation in September 2006, urinalysis revealed microhaematuria and moderate leukocyturia, lacking the significant growth of organisms on urine culture. However, an ultrasound scan of her kidneys exhibited signs of hydronephrosis of her left kidney that was reconfirmed as complete hydronephrotic failure by a Mercapto Acetyl Tri Glycine (MAG3) scan exhibiting 11% residual renal function. On clinical examination, a fixed and retroverted uterus and a hard nodular mass of about 1.5 cm in diameter originating from the upper third of the rectovaginal space (RVS) with queried infiltration of the anterior rectal wall were palpated.
The most frequent localisations of endometriotic lesions are the uterosacral ligaments, the pelvic peritoneum and the ovaries . In a subgroup of patients, endometriotic growth is deeply infiltrating, i.e. the presence of endometriotic tissue more than 5 mm under the peritoneum . Deep infiltrating endometriosis, which is commonly involving the RVS and the rectum, can be diagnosed in up to 10% of all patients with endometriosis . However, endometriotic involvement of the urinary system is rather rare and has been reported to occur in only 1–2% of all cases of pelvic endometriosis . Urinary endometriosis commonly involves the urinary bladder and/or the ureter. However, due to its rarity and asymptomatic course in the early stages of the disease, final diagnosis can be delayed . In the case presented, endometriotic tissue not only involved the rectosigmoid but also caused considerable distortion of the urinary bladder due to extensive involvement of the posterior wall. In addition, ureteral obstruction finally led to hydronephrosis with a subsequent long-standing impairment and, finally, a loss of renal function. Although there is evidence of temporary regression of endometriosis under hormonal treatment, such as GnRH analogues or gestagens, we suggest that, in cases of extensive involvement of extragenital tissues, such as the bowel or the urinary tract, surgical therapy is mandatory and should especially be considered in patients with subfertility.
- Gao X, Outley J, Botteman M, Spalding J, Simon JA, Pashos CL (2006) Economic burden of endometriosis. Fertil Steril 86(6):1561–1572PubMedView ArticleGoogle Scholar
- Jones KD, Sutton C (2002) Endometriosis. Emphasis on medical treatment is misleading. BMJ 324:115PubMedView ArticleGoogle Scholar
- Olive DL, Pritts EA (2002) The treatment of endometriosis: a review of the evidence. Ann N Y Acad Sci 955:360–372PubMedView ArticleGoogle Scholar
- Ferrero S, Abbamonte LH, Giordano M, Ragni N, Remorgida V. (2006) Deep dyspareunia and sex life after laparoscopic excision of endometriosis. Hum Reprod 22:1142–1148PubMedView ArticleGoogle Scholar
- Lyons SD, Chew SS, Thomson AJ, Lenart M, Camaris C, Vancaillie TG, Abbott JA (2006) Clinical and quality-of-life outcomes after fertility-sparing laparoscopic surgery with bowel resection for severe endometriosis. J Minim Invasive Gynecol 13(5):436–441PubMedView ArticleGoogle Scholar
- Garry R, Clayton R, Hawe J (2000). The effect of endometriosis and its radical laparoscopic excision on quality of life indicators. BJOG 107(1):44–54PubMedView ArticleGoogle Scholar
- Redwine DB, Wright JT (2001) Laparoscopic treatment of complete obliteration of the cul-de-sac associated with endometriosis: long-term follow-up of en bloc resection. Fertil Steril 76(2):358–365PubMedView ArticleGoogle Scholar
- Ford J, English J, Miles WA, Giannopoulos T (2004) Pain, quality of life and complications following the radical resection of rectovaginal endometriosis. BJOG 111(4):353–356PubMedView ArticleGoogle Scholar
- Keckstein J, Ulrich U, Kandolf O, Wiesinger H, Wustlich M (2003) Laparoscopic therapy of intestinal endometriosis and the ranking of drug treatment (in German). Zentralbl Gynakol 125(7–8):259–266PubMedGoogle Scholar
- Vercellini P, Trespidi L, De Giorgi O, Cortesi I, Parazzini F, Crosignani PG (1996) Endometriosis and pelvic pain: relation to disease stage and localization. Fertil Steril 65(2):299–304PubMedGoogle Scholar
- Cornillie FJ, Oosterlynck D, Lauweryns JM, Koninckx PR (1990) Deeply infiltrating pelvic endometriosis: histology and clinical significance. Fertil Steril 53:978–983PubMedGoogle Scholar
- Gustilo-Ashby AM, Paraiso MF (2006) Treatment of urinary tract endometriosis. J Minim Invasive Gynecol 13(6):559–565PubMedView ArticleGoogle Scholar
- Schneider A, Touloupidis S, Papatsoris AG, Triantafyllidis A, Kollias A, Schweppe KW (2006) Endometriosis of the urinary tract in women of reproductive age. Int J Urol 13(7):902–904PubMedView ArticleGoogle Scholar