- Original Article
- Open Access
Comparison of the modified McIndoe and modified laparoscopic Vecchietti techniques for the creation of a neovagina in Rokitansky syndrome
© Springer-Verlag 2008
- Received: 4 October 2007
- Accepted: 7 January 2008
- Published: 5 March 2008
The aim of this retrospective clinical study was to compare the effectiveness and long-term anatomic and functional results of the modified laparoscopic Vecchietti and modified McIndoe techniques used to treat Rokitansky syndrome. Neovaginas were created either with the modified laparoscopic Vecchietti technique or with the modified McIndoe technique in 21 patients with Rokitansky syndrome aged between 17 and 40 years (mean 23 years) who wished to begin sexual intercourse. Anatomic success was defined as a neovagina longer than 6 cm and the easy introduction of two fingers. Functional success was achieved if the patient reported satisfactory sexual intercourse starting from 6 months after surgery. The performance of both techniques was efficacious. However, the postoperative hospital stay and operation times of the modified laparoscopic Vecchietti technique were shorter than those of the modified McIndoe technique and the modified laparoscopic Vecchietti technique was less painful than the modified McIndoe technique.
- Modified laparoscopic Vecchietti technique
- McIndoe technique
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the most common congenital absence of the vagina and is characterized by a rudimentary uterus and normal fallopian tubes and ovaries. Its prevalence is 1 in 5,000 female newborns . It has no standardized treatment yet, but many techniques for creating a neovagina have been proposed in the past. The most widely used method has been the one described by McIndoe and Bannister in 1938 , in which a split-thickness skin graft is used to cover a mold inserted into a surgically created space between the bladder and the rectum.
On the other hand, during the last 30 years in Europe, the most commonly used method for the creation of a neovagina has been the one proposed by Vecchietti in 1965 . In 1994, Fedele et al. described a laparoscopic version of the Vecchietti method that has been proven to be safe and effective .
Both techniques’ effectiveness and practicability were compared in this study.
From April 2002 to July 2006, 21 patients with MRKH syndrome were surgically treated. The study was approved by the university’s ethical committee and an informed consent was signed by all patients.
The age of the patients ranged between 17 and 40 years, with a mean of 23 years. Patients below 17 years of age and those with chromosome anomaly were not included in the study.
Routine abdominal and rectal ultrasounds were performed on all patients for pelvic organ (uterus, ovaries, bladder) localizations. Ovaries were in their normal anatomical positions in all patients. Routine intravenous pyelogram (IVP) was performed on all patients to check for ureter and renal anomalies. Five patients had an ectopic kidney. One patient did not have a fifth finger on her left hand. Karyotype analysis was performed on all patients.
All patients’ main complaint was primary amenorrhea and being unable to have intercourse. MRKH syndrome’s diagnostic criteria are normal secondary sex characteristics, normal external genitalia, blind vaginal pouch and absent uterus, and the presence of normal tubes and ovaries. All patients’ karyotype was 46 XX.
Non-surgical methods like the Frank method are not used in our clinic. Each operation was performed by the same team experienced with each technique (gynecologist/oncologist and plastic surgeon for the modified McIndoe technique and a laparoscopic surgeon for the Vecchietti technique). Each team performed the operation that they are experienced in on the patients they examined. Each team was consulting on different days in the polyclinic; therefore, the allocation of patients to a specific team depended on the team which was on duty that day. Since all procedures were performed by surgeons experienced in each technique, any possible complication difference was not due to the experience of the surgeon, but to the operation technique itself. An informed consent was signed by all patients. The modified laparoscopic Vecchietti operation was performed on 10 patients (Group 1) and the modified McIndoe operation on 11 patients (Group 2).
In the McIndoe technique (Group 2), a graft was taken from the thigh or the scalp. The patient was placed in the lithotomy position and a transverse incision was made through the mucosa of the vaginal vestibule. The space between the urethra and bladder was anteriorily dissected and the rectum was posteriorly dissected until the undersurface of the peritoneum was reached. A plastic surgeon spread the split-thickness skin graft on a multiholed rigid plastic mold, covered the skin graft with fibringlue, and inserted it into the dissected space. The skin graft was sutured to the hymenal skin. In the ten days following the surgery, at least two dressings were done under general anesthesia by irrigation with Batticon solution. Antibiotic cream (Furacin; Eczacıbaşı, Turkey) and estrogen cream (Ovestin) was spread on the mold before replacing it. A semisolid silicone mold 2.5-cm wide and 12-cm long, which remained in place 24 h a day for at least 6 months after the operation, was used by the patient . The mold could be removed for sexual intercourse. Antibiotic cream (Furacin; Eczacıbaşı, Turkey) and estrogen cream (Ovestin) were spread on the mold before insetting it into the vagina. The patients were allowed to start sexual intercourse 1 month after hospital discharge.
Clinical follow-up was planned at 1, 3, 6, and 12 months after the operations and every 6 months thereafter. At each visit, the patients were questioned about the quality of their sexual life and about vaginal discharge. Vaginal and rectal examinations, vaginal cytology, and microbiology tests were performed. Postoperative neovaginal depth was measured by inserting molds of various lengths into the vagina. The criteria for anatomic success was a neovagina greater than 6 cm long and the easy introduction of two fingers within 6 months of corrective surgery.
Data analysis was performed using the SPSS package program version 14.0. All parameters are shown as the mean. The Mann-Whitney U- and the Chi-square tests were used. p<0.005 was considered to be statistically significant.
The average blind vaginal pouch was similar in both groups (p>0.005).
Analysis of all cases
Number of patients
Secondary sex characteristics
Number of married patients
Position of ovaries
The average retrieval time of the bean was 8 (6–10) days. The mean hospital stay was 8 days in Group 1 and 19 days in Group 2 (p>0.005). Most patients used their dilators in the first two months, but some who had regular intercourse did not. Because they were single, two patients were required to use their dilators as prescribed until starting sexual intercourse. There were hairs on the squamous epithelium of one neovagina of Group 2, but this did not cause any inconvenience during intercourse.
In Group 2, three patients had a postoperative infection in the neovagina and this was supported by microbiologic cultures (p>0.005).
Comparison between both procedures
No. of patients
Hemoglobin fall (gr/dl)
Postoperative analgesy needed
After the diagnosis of Rokitansky syndrome, usually during adolescent years, the creation of a neovagina should be delayed until the time of planned sexual intercourse due to the psychological and sociological problems caused by the use of molds in women not having sexual intercourse. In their study, Buss and Lee  had two rectovaginal fistulas and one graft failure after performing the McIndoe vaginoplasty, and five patients required additional reconstructive vaginal surgery. In 1996, Alessandrescu et al.  included 201 cases in their study. They reported no mortality, two rectal perforations (1%), eight graft infections (4%), and 11 infections of graft site origin (5.5%). They concluded that the McIndoe procedure is simple and has low morbidity and high success. The patients in Roberts et al.’s  study underwent a McIndoe vaginoplasty, after which, all neovaginal creations were successful. They also concluded that the McIndoe procedure has proved to be an excellent option for patients in whom conservative dilatation techniques failed and in patients who refused to attempt any dilatation. Højsgaard et al.’s  study reported complications such as the lack of skin graft take, bleeding, urethrovaginal fistula, perforation of the rectum, rectovaginal fistula, and vaginal stricture, which were treated to lead to satisfactory final results. Except for the bladder perforation, such serious complications were not encountered in the present study, which was, perhaps, due to the low number of cases.
According to Fedele et al. , the laparoscopic Vecchietti technique has numerous advantages. First, there is no need to dissect the vesicorectal space; a surgical step that carries some risks and complications. Second, the procedure does not cause any scars such as those associated with the technique of skin grafting. Third, the procedure is quick and does not require plastic surgery. Finally, the neovagina becomes coated with an iodine-positive stratified squamous epithelium similar to that of a normal vagina.
In this study, almost twice the amount of time was required to carry out the McIndoe procedure. Patients in Group 2 also received anesthesia for the dressings and required more analgesia during the postoperative period.
Hairs were found in the neovagina of one patient in Group 2. It is thought that the cause of this was that the graft, which was taken from the scalp, must have been full-thickness instead of split-thickness. The hairs eventually fell off. In addition, postoperative vaginal infection, which was treated by serum and Batticon antiseptic solution (polyvinylpyrolidone–iodine complex; Adeka, Turkey), irrigation, and local and systemic antibiotics, was observed in Group 2.
In the modified McIndoe group, 27.3% of patients assessed their pain as moderate and 72.7% assessed it as severe. In the Vecchietti group, all patients assessed their pain as moderate.
The longer hospital stay in Group 2 was due to the fact that at least two dressings were done under general anesthesia by the surgeon him/herself to see whether neovascularization had taken place and to teach the patient sterile dressing techniques.
The cost of performing the modified McIndoe technique was twice as much as the modified Vecchietti technique because it involves three departments (anesthesiology, plastic surgery, gynecology) as opposed to two (anesthesiology, gynecology), requires more surgical interventions for the graft, is a longer operation, and requires more analgesia and a longer hospitalization.
The lengths of the neovaginas were almost the same in both groups. Anatomic success was defined as a neovagina longer than 6 cm and the easy introduction of two fingers .
In conclusion, the modified laparoscopic Vecchietti technique is more cost-effective and less painful than the McIndoe technique. Because of its low morbidity and high effectiveness, the modified laparoscopic Vecchietti technique is concluded to be the more suitable technique for creating neovaginas in women with MRKH syndrome.
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