Transcervical intrauterine bupivacaine for the management of postoperative pain following endometrial balloon ablation—a pre-trial toxicity study

Table 1 Serum bupivacaine levels, pain score and postoperative analgesia in study participants

Participant number (study group)	Serum bupivacaine (3 h postoperative; mg/L)	Pain scores at recovery/discharge^a	Diclofenac	Paracetamol	Other analgesia	Morphine (total dose)
1	<0.1	0/1	100 mg PR	1 g PR	Codeine 60 mg	–
2^b	0.1	3/0	100 mg PR	1 g iv	Codeine 60 mg	10 mg
3	Wrong sample	0/0	100 mg PR	1 g PR	–	–
4^b	0.5	2/0	50 mg iv	1 g	Buscopan 10 mg	10 mg
5	<0.1	1/1	–	–	Codeine 60 mg	–
6	0.1	1/1	75 mg iv	1 g PR	–	–
7	1.3	1/1	50 mg iv	1 g iv	–	–
8	<0.1	2/1	100 mg PR	1 g PR	Codeine 60 mg	–
8	<0.1	2/1	100 mg PR	1 g iv	Codeine 60 mg	–
9	<0.1	0/1	75 mg iv	1 g PR	Co-codamol × 2	–
10	0.5	1/1	75 mg iv	1 g PR	Codeine phos 60 mg	–

^aPain score—verbal scale of 0–4 (standard use in recovery—East Lancashire Hospital NHS Trust; 0—none, 1—mild pain, 2—mild but moderate on movement, 3—moderate but severe on movement and 4—severe at rest)
^bRequired overnight stay