From: Splenic rupture: a rare presentation of metastatic choriocarcinoma
FIGO anatomical staging | ||||
Stage I | Disease confined to the uterus | |||
Stage II | GTN extends outside of the uterus, but is limited to the genital structures (adnexa vagina, broad ligament) | |||
Stage III | GTN extends to the lungs, with or without known genital tract involvement | |||
Stage IV | All other metastatic | |||
Modified WHO prognostic scoring system as adapted by FIGO | ||||
Scores | 0 | 1 | 2 | 4 |
Age | <40 | ≥40 | – | – |
Antecedent pregnancy | Mole | Abortion | Term | – |
Interval months from index pregnancy | <4 | 4–6 | 7–12 | >12 |
Pretreatment serum hCG (IU/L) | <103 | 103–104 | 104–105 | >105 |
Largest tumor size (including uterus) | <3 | 3–4 cm | ≥5 cm | – |
Site of metastases | Lung | Spleen, kidney | Gastrointestinal | Liver, brain |
Number of metastases | – | 1–4 | 5–8 | >8 |
Previous failed chemotherapy | – | – | Single drug | 2 or more drugs |