Spontaneous intramyometrial pregnancy mimicking an intramural myoma: a diagnostic challenge
© Springer-Verlag 2012
Received: 30 March 2012
Accepted: 11 April 2012
Published: 17 June 2012
This study describes the diagnosis and treatment of a spontaneous intramyometrial pregnancy by a case report and review of the literature at a university hospital center. A 24-year-old woman presented with a spontaneous intramyometrial pregnancy without any previous uterine surgery. Successful laparoscopic resection and myometrial correction were performed. The presence of trophoblastic tissue was confirmed and the myometrium revealed complete healing at postoperative MRI. Intramyometrial pregnancy can occur without previous uterine surgery or uterine manipulation and may be difficult to diagnose. Conservative laparoscopic excision is possible without damage to myometrial integrity.
Intramyometrial pregnancy is a very rare type of ectopic pregnancy. This uncommon condition has been estimated to occur in less than 1 % of all ectopic gestations . An intramyometrial pregnancy is located within the uterine wall, completely surrounded by myometrium, and separated from the uterine cavity and fallopian tubes , but confusion remains in the literature as to its physiopathology. Ong et al. explain intramyometrial ectopic pregnancy by increased lytic activity of the syncytiotrophoblast and defective decidualization, allowing the conceptus to penetrate the myometrium . But, as described by Pijnenborg et al., in normal pregnancy, the decidua attracts the trophoblast and both intravascular and interstitial trophoblasts invade the inner myometrium . Risk factors have been identified to explain the pathogenesis, including previous uterine trauma causing a sinus tract within the endometrium [1, 3, 4], implantation on a focus of intramural adenomyosis [5, 6], or difficult embryo transfer with a false passage [1, 7–9]. Others have described invasion of the uterine wall by placenta accreta and subsequent growth of the fetus deep within the myometrium .
Due to late and often difficult ultrasonographic diagnosis, the gestational sac can grow deep in the myometrium and cause the main complication, namely uterine rupture associated with life-threatening hemorrhage reported to occur between week 11 and week 30 of gestation . To our knowledge, this is the first reported case of intramyometrial pregnancy to occur without any previous surgery or uterine manipulation.
A 24-year-old woman with a history of spontaneous abortion without dilatation–curettage was referred as an emergency case to our department with acute pelvic pain and suspected ectopic pregnancy. Vaginal examination provoked acute pain upon palpation of the right adnexa, while the uterus appeared to be of normal size. HCG was 102 IU/l, and vaginal ultrasound confirmed a normal-sized uterus, but containing a heterogeneous subserosal mass measuring 35 × 30 mm and regularly circumscribed. An adenomyoma or necrotic uterine myoma was suspected. Both adnexa looked normal, but the Douglas pouch revealed the presence of blood. Because of acute pain at vaginal examination, low HCG level, and ultrasound status, ectopic pregnancy was suspected and diagnostic laparoscopy was performed.
At laparoscopy, the uterus showed a subserosal 3 cm mass located on the right side of the uterus below the right utero-ovarian ligament. Fifty milliliters of blood was found in the Douglas pouch. The fallopian tubes were both unremarkable, and no ectopic pregnancy was identified. The abdominal cavity was flushed with physiological serum. On day 1, the HCG level was 44 IU/l and the patient did not present with any abdominal pain. She was then discharged from the hospital, and monitoring of HCG levels was proposed. On day 10, her HCG was less than 1.2 IU/ml. One week after the first laparoscopy, vaginal examination revealed a 7-week-sized uterus, with tenderness on the right side.
Pelvic MRI performed 3 months after surgery showed complete healing of the myometrium. No uterine scarring was visible (Fig. 3b). Clinical examination revealed a normal-sized uterus, and the patient did not experience any abdominal pain.
Intramyometrial ectopic pregnancy is uncommon. Its etiology remains unclear, but most authors attribute it to a sinus tract within the endometrium caused by previous uterine surgery or manipulation [1, 3, 4], adenomyosis [5, 6], or a difficult embryo transfer [1, 7–9]. Leyder et al. described intramyometrial pregnancy after an embryo transfer following uterine artery embolization , and Glass et al. described a case in a woman with tuberous sclerosis . In our case, there was no previous uterine surgery or previous intrauterine manipulation and no sinus tract was found during hysteroscopy. This supports the theory of uterine wall invasion by placenta accreta and subsequent growth of the fetus deep in the myometrium, as described by Bernstein et al. .
Differential diagnosis based on 2D ultrasound remains difficult and may suggest a number of possibilities, including interstitial or cornual ectopic pregnancy, degenerating myoma, pregnancy in a congenitally abnormal uterus , sarcoma or molar pregnancy , or unruptured intramyometrial pregnancy.
The use of pelvic MRI allows visualization of multiple scan planes and helps to define the distance between the intramyometrial pregnancy and the uterine cavity [1, 3, 11, 12]. Ko et al. proposed MRI to distinguish an unruptured intramyometrial pregnancy, which looks like a homogeneous hyperintense mass on T2-weighted images, from a ruptured one, that shows a heterogeneous signal intensity on T2-weighted images. On the other hand, contrast-enhanced T1-weighted images show tree-like, solid components resulting from hemorrhages at various times . In our case, T2-weighted views revealed a heterogeneous mass, but T1-weighted views showed a more homogeneous mass with only few remaining spots of contrast enhancement.
Therapies for intramyometrial pregnancies
Number of patients
Ginsburg et al. 
16 week pregnancy with hemoperitoneum and suspected uterine rupture
Katano et al. 
1 D/C for a partial mole
US and MRI: GS with 22-mm CRL + FHB (−)
Laparoscopy: MTX injection into the GS + 2 US-guided injections of MTX
HCG (−) on 19th POD, HSG: pooling of contrast medium in the region of intramyometrial pregnancy
Bernstein et al. 
1 D/C + 1 spontaneous abortion
Transabdominal US: GS with a yolk sac
Spontaneous HCG (−) on 10th POD, HSG: small endometrial polyp with a moderately arcuate uterus
Lee et al. 
Right adnexectomy for torsion
US: GS with CRL and yolk sac
Ko et al. 
5 D/C (last D/C 4 weeks before)
US and MRI: GS in the posterior wall
Alternating IM MTX and leucovorin for 8 days
HCG (−) after 8 weeks
Park et al. 
Myomectomy by laparotomy + transfer of 3 embryos
US: GS in subserosal region of the posterior wall with CRL and yolk sac
Laparoscopy: incision, aspiration, and interrupted sutures
HCG (−) on 14th POD, subsequent pregnancy after 4 frozen embryos transferred on 92nd POD + placental invasion of the myometrium
Ong et al. 
Bilateral endometriomas and adenomyosis
US: GS + CRL 3 mm + FHB (+)
US-guided intrafetal KCl and intra-amniotic MTX injections
HCG (−) on 82nd POD
Leyder et al. 
Uterine artery embolization for symptomatic uterine fibroids + transfer of 2 embryos
US and MRI
Systemic MTX injection
Glass et al. 
US and MRI: GS without CRL, failure of US-guided curettage
Laparoscopy + laparotomic enucleation due to hemoperitoneum and size of the mass
Nabeshima et al. 
Left salpingectomy for ectopic tubal pregnancy and 1 C/S
US: GS + FHB (+)
Laparoscopy: myometrial injection of vasopression + section with Harmonic® scalpel + excision of surrounding myometrium + running suture + fibrin glue
HCG (−) on 14th POD, HSG: no change compared with before pregnancy
Spontaneous abortion without D/C
US and MRI
Laparoscopy: CO2 laser section + no excision of myometrium + 2-layer running suture
Low HCG after first diagnostic laparoscopy, complete healing of the myometrium after second laparoscopy
Conservative medical management can be achieved using systemic intramuscular administration of methotrexate  or ultrasound-guided methotrexate injection into the chorionic cavity of patients with an intramyometrial pregnancy without a fetal heartbeat [12, 13]. Intra-amniotic injection of methotrexate can also be associated with intrafetal injection of potassium chloride in case of intramyometrial pregnancy with the presence of a fetal heartbeat .
Laparoscopic treatment with opening of the surrounding myometrium and suture by interrupted stitches was performed in a patient with an intramyometrial pregnancy in a myomectomy scar  and another who had undergone previous left salpingectomy . Enucleation by laparotomy was also carried out for intramyometrial pregnancy after right adnexectomy  and due to massive hemoperitoneum .
Ginsburg et al. reported a case of suspected uterine rupture at 16 gestational weeks with hemoperitoneum. Hysterectomy was performed, and pathological examination showed the presence of an intramyometrial pregnancy .
In our case, despite a low HCG level, the patient still felt pain at vaginal examination. This led us to perform pelvic MRI, which was unable to differentiate between adenomyoma, necrotic leiomyoma, and intramyometrial pregnancy.
The low HCG level did not exclude uterine rupture. It can be compared to some ectopic pregnancies that occur with negative HCG levels. Ectopic pregnancy is due to growth of trophoblasts into the tubal mucosa that can cause erosion of tubal vessels, resulting in hematoma formation and tubal swelling. The persistence of ectopic pregnancy without rupture may lead, in some cases, to degeneration of trophoblasts and cessation of HCG production. Spontaneous abortion or repeated minor bleeding episodes in this type of chronic ectopic pregnancy can cause subsequent rupture associated with hemoperitoneum, with low or negative HCG levels . Uterine conservative surgery was thus mandatory in our patient, with successful complete healing of the intramyometrial pregnancy site.
Intramyometrial ectopic pregnancy is a rare life-threatening entity. Our case suggests that spontaneous intramyometrial pregnancy can occur without any previous uterine surgery or intrauterine manipulation. Because of the paucity of cases described in the literature, diagnosis remains difficult and treatment tends to be conservative. Our case suggests that even in case of negative HCG levels, we cannot exclude ruptured intramyometrial pregnancy, and laparoscopic excision can be performed without damaging uterine wall integrity.
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