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Table 2 Efficacy of 4 % icodextrin solution on the prevention of adhesion formation in gynaecological surgery

From: A meta-analysis of the use of 4 % icodextrin solution to prevent adhesion formation after gynaecological surgery

Study

Adhesions at SLL

Brown et al. [1]

Number of patients free from de novo adhesions:

 OR 1.49 [1.01, 2.21]

Adhesion score at SLL:

 outcome not analysed

Adhesion score reduction at SLL:

 MD 1.51 [0.32 2.70]

Mean % reduction in extent of adhesions:

 MD 5.10 [−4.67, 14.87]

Mean % reduction in severity of adhesions:

 MD 2.70 [−5.73, 11.13]

Improvement in adhesion score:

 outcome not analysed

Worsening in adhesion score:

 outcome not analysed

diZerega et al. [3]

Number of patients free from de novo adhesions:

 outcome not analysed

Adhesion score at SLL:

 outcome not analysed

Adhesion score reduction at SLLa:

 MD 0.10 [−0.50, 0.70]

Mean % reduction in extent of adhesions:

 MD 21.00 [−42.36, 84.36]

Mean % reduction in severity of adhesions:

 MD 47.00 [−15.76, 109.76]

Improvement in adhesion score:

 OR 3.24 [0.86, 12.12]

Worsening in adhesion score:

 OR 0.28 [0.07, 1.21]

Trew et al. [5]

Number of patients free from de novo adhesions:

 OR 0.92 [0.55, 1.54]

Adhesion score at SLL:

 MD −0.29 [−2.97, 2.39]

Adhesion score reduction at SLL:

 outcome not analysed

Mean % reduction in extent of adhesions:

 outcome not analysed

Mean % reduction in severity of adhesions:

 outcome not analysed

Improvement in adhesion score:

 outcome not analysed

Worsening in adhesion score:

 outcome not analysed

  1. SLL second-look laparoscopy, OR odds ratio, MD mean difference, SD standard deviation
  2. aCalculated by subtracting the mean score at SLL from the mean baseline score. SD calculated by assuming a within-patient correlation of 0.5 for the sensitivity analysis