Cross-linked xenogenic collagen implantation in the sheep model for vaginal surgery

Table 2 Histological scores of host response and connective tissue formation following insertion of ACM and PP in the vagina and abdominal wall

Histology	Abdomen	Anterior vagina	Pair comparison	Anterior vagina	Unpaired comparison
Histology	ACM		Pair comparison	PP	Unpaired comparison
	N = 10	N = 10		N = 6
FBGC	0.8 (0.88)	0.1 (0.53)	0.0078	0.40 (0.25)
PMN	0.15 (0.38)	0.2 (0.67)		0.05 (0.23)
Vascularity	1.0 (0.4)	1.15 (0.3)		2.05 (0.55)	0.0023
Collagen organization	1.5 (1.4)	1.4 (0.35)		1.3 (0.55)
Collagen composition	1.8 (0.4)	2.1 (0.4)		2.3 (0.55)
Collagen amount	2.7 (0.2)	2.5 (0.2)	0.0201	1.9 (0.35)	0.0061
Calcification	4/10	1/10		0/6
Scores at the interface with identifiable material on histology	N = 7	N = 3		N = 6
FBGC	1.1 (0.7)	0.8 (0.35)		0.40 (0.25)
PMN	0.1 (0.45)	1.8 (0.85)		0.05 (0.23)
Vascularity	0.7 (0.45)	1.5 (0.45)		2.05 (0.55)
Collagen organization	1.4 (1.0)	0.8 (0.5)		1.3 (0.55)
Collagen composition	1.8 (0.3)	2.4 (0.3)		2.3 (0.55)
Collagen amount	2.8 (0.3)	2.8 (0.1)		1.9 (0.35)

Scores are displayed for all explanted specimens and also for those with identifiable ACM. For later, statistics was not carried out due to a few specimens. Data for vaginal PP implants were previously published by Feola et al. 2014 [17]
FBGC foreign body giant cell, PMN polymorphonuclears