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Table 5 Tumors inconsistent with World Health Organization 2003 leiomyosarcoma criteria

From: The prevalence of occult leiomyosarcoma at surgery for presumed uterine fibroids: a meta-analysis

Author/date type

Leiomyoma sub-type

Age (years)

Pathology

Recurrence

∞Leibsohn/1990 retro

Atypical

36

6 mitoses/10 HPF, “poorly demarcated,” cellular atypia

NED 6 months

 

Atypical

48

7 mitoses/10 HPF, cellular atypia

NED 16 months

∞Parker/1994 retro

Atypical

30

Irregular infiltrative borders, mild nuclear atypia, 5–8 mitoses/10 HPF

NED “years”

Seki/1992 retro

Mitotically active

33

6 mitoses/10 HPF, no cellular atypia

NED 11 months

 

Mitotically active

34

5 mitoses/10 HPF, no cellular atypia

NED 57 months

 

Mitotically active

43

8 mitoses/10 HPF, no cellular atypia

NED 61 months

 

Mitotically active

43

9 mitoses/10 HPF, no cellular atypia

NED 72 months

  1. HPF high-powered field
  2. Retro retrospective
  3. included in FDA analysis
  4. NED no evidence of disease