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Table 5 Tumors inconsistent with World Health Organization 2003 leiomyosarcoma criteria

From: The prevalence of occult leiomyosarcoma at surgery for presumed uterine fibroids: a meta-analysis

Author/date type Leiomyoma sub-type Age (years) Pathology Recurrence
∞Leibsohn/1990 retro Atypical 36 6 mitoses/10 HPF, “poorly demarcated,” cellular atypia NED 6 months
  Atypical 48 7 mitoses/10 HPF, cellular atypia NED 16 months
∞Parker/1994 retro Atypical 30 Irregular infiltrative borders, mild nuclear atypia, 5–8 mitoses/10 HPF NED “years”
Seki/1992 retro Mitotically active 33 6 mitoses/10 HPF, no cellular atypia NED 11 months
  Mitotically active 34 5 mitoses/10 HPF, no cellular atypia NED 57 months
  Mitotically active 43 8 mitoses/10 HPF, no cellular atypia NED 61 months
  Mitotically active 43 9 mitoses/10 HPF, no cellular atypia NED 72 months
  1. HPF high-powered field
  2. Retro retrospective
  3. included in FDA analysis
  4. NED no evidence of disease