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Table 6 Primary systemic MTX treatment of interstitial pregnancy

From: Elective uterine artery embolization prior to laparoscopic resection of interstitial pregnancy: two cases and literature review

Author

N

Initial β-hCG

Systemic MTX treatment

Hospital stay

Negative β-hCG

Complications

Success

Tanaka et al. [52]

1

64,000

30 mg IM day 0 + 15 mg/d IM 5 days, 3 cycles

N/A

3

Liver function ↓

1/1

Benifla et al. [27]

2

364–5340

15 mg/d IM for 5 days

3

3 (1/2)

–

1/2

 

2

430–450

1 mg/kg/d IM for 4 days

3

3–6

–

2/2

Hajenius et al. [53]

8

410–81,000

1 mg/kg/d IM on day 1, 3, 5, 7

N/A

7–21

–

8/8

Galimberti and Jones [54]

1

7072

50 mg/m2 IM

N/A

N/A

–

0/1

Bernardini et al. [55]

1

12,470

100 mg IM

N/A

14

–

1/1

Fisch et al. [56]

1

102,000

50 mg/m2 IM on day 1, 3, 5, 7

11

7

–

0/1

Sagiv et al. [57]

1

28,166

2 × 75 mg IM

4

N/A

–

0/1

Lalchandani et al. [58]

1

12,338

400 mg/w IV for 8 weeks

N/A

8

–

1/1

Verity et al. [59]

1

1060

2 × 75 mg IM

N/A

7

–

1/1

 

1

5560

2 × 50 mg/m2 IM, 48 h apart

N/A

8–9

–

1/1

 

1

3510

1 mg/kg IM, 2 doses

N/A

4

–

1/1

 

1

9070

1 mg/kg IM, 1 dose

–

6–7

–

1/1

Advincula and Senapati [60]

1

62,889

N/A

N/A

N/A

N/A

0/1

Jermy et al. [24]

17

32–31,381

50 mg/m2 IM°

0–40

3–13

–

16/17

Ophir et al. [34]

1

33,689

50 mg/m2 IM°

7

8

–

0/1

Reid and Buddha [61]

1

4680

50 mg/m2 IM

N/A

7

–

1/1

Rodriguez et al. [62]

7

1592–75,868

50 mg/m2 IM°

N/A

2–15

–

7/7

Tulandi et al. [39]

4

2627–6739

50 mg/m2 IM

N/A

7 (2/4)

–

2/4

Cassik et al. [28]

5

793–41,150

2 × 50 mg/m2 IM, 48 h apart

N/A

3–7

Obstipation 2/5

Neuropathy 1/5

Mild ↓ liver 1/5

4/5

Deruelle et al. [35]

1

17,785

2 × 1 mg/kg IM

6

10

–

0/1

Klemm et al. [63]

3

11,743–22,134

1 mg/kg/d IV on day 1, 3, 5, 7; 2 cycles

N/A

N/A

–

3/3

Araujo et al. [64]

1

4815

50 mg IM

N/A

N/A

–

0/1

Yang et al. [17]

1

29,454

1 mg/kg IM

6

4

–

0/1

Fujioka et al. [65]

1

11,430

50 mg/m2 IM

N/A

N/A

–

0/1

Api and Api [66]

1

11,706

1 mg/kg IM

1

1

–

0/1

Günenç et al. [67]

1

8314

2 × 1 mg/kg IM

N/A

N/A

–

0/1

Tamarit et al. [36]

2

4394–8970

2 × 50 mg IM

1

10

–

0/2

Kato et al. [68]

1

90,000

50 mg/m2 IM

N/A

N/A

–

0/1

Lee et al. [69]

1

3029

4 × 1 mg/kg IM

3

N/A

–

0/1

Gomez et al. [70]

2

3724–4116

70–75 mg + oral Mifepristone

2

5–7

–

2/2

Monia et al. [71]

3

3000–111,633

1–4× IM

N/A

2–6 (2/3)

–

2/3

Szylit et al. [72]

1

21,281

2 × 50 mg/m2 IM, 48 h apart

N/A

N/A

–

0/1

Ahn et al. [45]

1

4478

Multiple doses

4

N/A

–

1/1

Berretta et al. [37]

1

49,997

2 × 80 mg IM

11

N/A

–

0/1

Sagiv et al. [73]

4

4304–28,166

50 mg/m2 IM°

N/A

N/A

–

1/4

Surbone et al. [74]

3

2974–15,022

1 mg/kg IM

N/A

N/A

–

2/3

Fritz et al. [75]

1

8200

50 mg/m2 IM

N/A

N/A

–

0/1

Hiersch et al. [25]

14

15,764

1 mg/kg/d IM on day 1, 3, 5, 7

N/A

N/A

–

9/14

 

3

< 2500

50 mg/m2 IM

1

N/A

–

3/3

Horne et al. [76]

5

2458–9730

50 mg/m2 IM°

N/A

10

–

5/5

Meddeb et al. [77]

1

6320

Single dose

N/A

N/A

PTD

0/1

Corioni et al. [78]

1

8681

1 mg/kg IM

11

9

–

1/1

Kim et al. [79]

1

35,890

Every 2 days for 4 weeks

N/A

17

Pseudocyst

1/1

Singh et al. [80]

1

89,000

1 mg/kg IM, 3 doses

21

12

–

1/1

Tanaka et al. [26]

33

230–106,634

100 mg IV in bolus followed by 200 mg IV

1–4

3–19

–

31/33

Nikodijevic et al. [48]

2

19,563

N/A

N/A

4

–

3/3

Kahramanoglu et al. [81]

1

1263

50 mg/m2 IM

7

6

–

1/1

Kim et al. [12]

5

375–102,970

1 mg/kg/d IM on day 1, 3, 5, 7

N/A

N/A

N/A

14/30

 

24

 

50 mg/m2 IM

N/A

N/A

N/A

 
 

1

 

100 mg IV in bolus followed by 200 mg IV

N/A

N/A

N/A

 
  1. N number of cases, β-hCG mIU/ml, MTX methotrexate, IM intramuscular, IV intravenous, hospital stay days, negative β-hCG weeks, PTD persistent trophoblastic disease
  2. °With a second injection, if β-hCG decrease is less than 15% from days 4 to 7
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