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Table 6 Primary systemic MTX treatment of interstitial pregnancy

From: Elective uterine artery embolization prior to laparoscopic resection of interstitial pregnancy: two cases and literature review

Author N Initial β-hCG Systemic MTX treatment Hospital stay Negative β-hCG Complications Success
Tanaka et al. [52] 1 64,000 30 mg IM day 0 + 15 mg/d IM 5 days, 3 cycles N/A 3 Liver function ↓ 1/1
Benifla et al. [27] 2 364–5340 15 mg/d IM for 5 days 3 3 (1/2) 1/2
  2 430–450 1 mg/kg/d IM for 4 days 3 3–6 2/2
Hajenius et al. [53] 8 410–81,000 1 mg/kg/d IM on day 1, 3, 5, 7 N/A 7–21 8/8
Galimberti and Jones [54] 1 7072 50 mg/m2 IM N/A N/A 0/1
Bernardini et al. [55] 1 12,470 100 mg IM N/A 14 1/1
Fisch et al. [56] 1 102,000 50 mg/m2 IM on day 1, 3, 5, 7 11 7 0/1
Sagiv et al. [57] 1 28,166 2 × 75 mg IM 4 N/A 0/1
Lalchandani et al. [58] 1 12,338 400 mg/w IV for 8 weeks N/A 8 1/1
Verity et al. [59] 1 1060 2 × 75 mg IM N/A 7 1/1
  1 5560 2 × 50 mg/m2 IM, 48 h apart N/A 8–9 1/1
  1 3510 1 mg/kg IM, 2 doses N/A 4 1/1
  1 9070 1 mg/kg IM, 1 dose 6–7 1/1
Advincula and Senapati [60] 1 62,889 N/A N/A N/A N/A 0/1
Jermy et al. [24] 17 32–31,381 50 mg/m2 IM° 0–40 3–13 16/17
Ophir et al. [34] 1 33,689 50 mg/m2 IM° 7 8 0/1
Reid and Buddha [61] 1 4680 50 mg/m2 IM N/A 7 1/1
Rodriguez et al. [62] 7 1592–75,868 50 mg/m2 IM° N/A 2–15 7/7
Tulandi et al. [39] 4 2627–6739 50 mg/m2 IM N/A 7 (2/4) 2/4
Cassik et al. [28] 5 793–41,150 2 × 50 mg/m2 IM, 48 h apart N/A 3–7 Obstipation 2/5 Neuropathy 1/5 Mild ↓ liver 1/5 4/5
Deruelle et al. [35] 1 17,785 2 × 1 mg/kg IM 6 10 0/1
Klemm et al. [63] 3 11,743–22,134 1 mg/kg/d IV on day 1, 3, 5, 7; 2 cycles N/A N/A 3/3
Araujo et al. [64] 1 4815 50 mg IM N/A N/A 0/1
Yang et al. [17] 1 29,454 1 mg/kg IM 6 4 0/1
Fujioka et al. [65] 1 11,430 50 mg/m2 IM N/A N/A 0/1
Api and Api [66] 1 11,706 1 mg/kg IM 1 1 0/1
Günenç et al. [67] 1 8314 2 × 1 mg/kg IM N/A N/A 0/1
Tamarit et al. [36] 2 4394–8970 2 × 50 mg IM 1 10 0/2
Kato et al. [68] 1 90,000 50 mg/m2 IM N/A N/A 0/1
Lee et al. [69] 1 3029 4 × 1 mg/kg IM 3 N/A 0/1
Gomez et al. [70] 2 3724–4116 70–75 mg + oral Mifepristone 2 5–7 2/2
Monia et al. [71] 3 3000–111,633 1–4× IM N/A 2–6 (2/3) 2/3
Szylit et al. [72] 1 21,281 2 × 50 mg/m2 IM, 48 h apart N/A N/A 0/1
Ahn et al. [45] 1 4478 Multiple doses 4 N/A 1/1
Berretta et al. [37] 1 49,997 2 × 80 mg IM 11 N/A 0/1
Sagiv et al. [73] 4 4304–28,166 50 mg/m2 IM° N/A N/A 1/4
Surbone et al. [74] 3 2974–15,022 1 mg/kg IM N/A N/A 2/3
Fritz et al. [75] 1 8200 50 mg/m2 IM N/A N/A 0/1
Hiersch et al. [25] 14 15,764 1 mg/kg/d IM on day 1, 3, 5, 7 N/A N/A 9/14
  3 < 2500 50 mg/m2 IM 1 N/A 3/3
Horne et al. [76] 5 2458–9730 50 mg/m2 IM° N/A 10 5/5
Meddeb et al. [77] 1 6320 Single dose N/A N/A PTD 0/1
Corioni et al. [78] 1 8681 1 mg/kg IM 11 9 1/1
Kim et al. [79] 1 35,890 Every 2 days for 4 weeks N/A 17 Pseudocyst 1/1
Singh et al. [80] 1 89,000 1 mg/kg IM, 3 doses 21 12 1/1
Tanaka et al. [26] 33 230–106,634 100 mg IV in bolus followed by 200 mg IV 1–4 3–19 31/33
Nikodijevic et al. [48] 2 19,563 N/A N/A 4 3/3
Kahramanoglu et al. [81] 1 1263 50 mg/m2 IM 7 6 1/1
Kim et al. [12] 5 375–102,970 1 mg/kg/d IM on day 1, 3, 5, 7 N/A N/A N/A 14/30
  24   50 mg/m2 IM N/A N/A N/A  
  1   100 mg IV in bolus followed by 200 mg IV N/A N/A N/A  
  1. N number of cases, β-hCG mIU/ml, MTX methotrexate, IM intramuscular, IV intravenous, hospital stay days, negative β-hCG weeks, PTD persistent trophoblastic disease
  2. °With a second injection, if β-hCG decrease is less than 15% from days 4 to 7