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Table 7 Primary local medical treatment of interstitial pregnancy

From: Elective uterine artery embolization prior to laparoscopic resection of interstitial pregnancy: two cases and literature review

Author N Initial β-hCG Local medical treatment Hospital stay Negative β-hCG Complications Success
Timor-Tritsch et al. [82] 1* 14,100 KCL 0.5 ml of 2 mEq/ml cornual N/A 6 (*) Miscarriage 1/1
1 1400 MTX 25 mg cornual 4 5 1/1
Benifla et al. [27] 2 16,000–43,000 MTX 1 mg/kg intrasaccular, UG1 3 (1/2) 6 (1/2) Bleeding 1/2 1/2
  6 360–10,000 MTX 1 mg/kg intrasaccular, UG/LG 3 1–3 6/6
  3* 15,000–25,205 KCL 2 mEq in 2 ml volume intrasaccular 3 * Miscarriage 2/3 3/3
Baker et al. [83] 1* 18,423 MTX 12.5 mg with 1 ml of 20% KCL 0 * 1/1
Wilkinson et al. [84] 1 10,500 MTX 40 mg N/A N/A 1/1
Lin et al. [85] 1 3256 MTX 50 mg with diluted vasopressin 2 2 1/1
Oyawoye et al. [86] 1* 78,685 MTX N/A * 1/1
Verity et al. [59] 1 5780 MTX 50 mg, LG2 N/A 9 1/1
  1 5578 MTX 50 mg, LG N/A 4 1/1
Tulandi et al. [39] 2 2627–6739 MTX, LG N/A 7 (1/2) 1/2
2   MTX N/A 7 2/2
Cassik et al. [28] 23 102–69,820 MTX 25 mg, UG3 N/A 3–14 21/23
Chou et al. [87] 1 6413 KCL 2.5 mEq, UG N/A 12 1/1
Narang and Kalu [88] 2 3700–40,000 MTX 50 mg/m2 N/A N/A 2/2
Andrés et al. [89] 3 6193–21,999 MTX 50 mg intrasaccular, UG4 1 4–10 Leukopenia 1/3 2/3
Monia et al. [71] 2 7909–64,000 MTX 20–40 mg5 N/A 2 2/2
  1 8400 MTX 60 mg N/A 4 1/1
Surbone et al. [74] 6 2974–15,022 MTX 1 mg/kg N/A N/A 5/6
Swank et al. [90] 1 90,504 MTX 50 mg5 7 7 1/1
Douysset et al. [46] 2 369–45,780 N/A N/A N/A 2/2
Framarino et al. [29] 14 2800–3200 MTX 25 mg N/A Max. 8 14/14
Yu et al. [91] 4* N/A MTX 1 mg/kg N/A N/A 4/4
Maçães et al. [92] 1 2776 MTX 25 mg with 2 mEq KCL N/A 8 1/1
Leggieri et al. [93] 1 5055 MTX 25 mg 4 3 1/1
Nikodijevic et al. [48] 3 19,563 MTX5 N/A 4 2/2
  1   MTX N/A N/A N/A 0/1
Kim et al. [12] 2 2292–59,090 MTX 1 mg/kg N/A N/A N/A 7/8
  6   MTX 1 mg/kg5 N/A N/A N/A  
  1. N number of cases, β-hCG mIU/ml, KCL potassium chloride, MTX methotrexate, UG under ultrasound guidance, LG under laparoscopic guidance, hospital stay days, negative β-hCG weeks
  2. *Heterotopic pregnancy: 1: MTX 1 mg/kg/d IM 3 days after, 2: MTX 50 mg IM on days 2 and 4, 3: in viable pregnancies + KCL intracardially (5/23), 4 MTX 50 mg/m2IM (2/3 patients), 5: systemic MTX