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Table 1 Women with progressive endometriosis after menopause in the absence of estrogens

From: Symptomatic endometriosis developing several years after menopause in the absence of increased circulating estrogen concentrations: a systematic review and seven case reports

Patient

Age

Menopause

 

BMI, kg/m2

Previous surgery

Medication

Indication for diagnosis

Final diagnosis

Comorbidities

Age

 

Age

Type

Endo

Type

Months

Pain type

Pain increasing

Finding

E2, pg/ml

CA125, U/mL

CT

MRI

US

Surgery

Case report 1

72

54

Spt

 

65

4

0

0

 

3

1

1

–

–

–

 

3

3

Diverticulitis

Case report 2

64

51

Surg

37

51

2

3

0

 

3

1

1 + 2 + 3

–

–

–

3

3

3

Diabetes, hypertension, obesity

Case report 3

62

45

Spt

31

57

 

3

1

3

3

1

1 + 3

–

–

–

3

3

–

Hypertension, obesity

Case report 4

43

36

Spt

24

36

2

3

0

 

3

1

1

–

–

–

0

0

3 + 4

 

Case report 5

37

32

Spt

27

32

4

3

1

6

3

1

1

–

–

–

3

3

–

Adenomyosis

Case report 6

52

48

Spt

–

50

1

5

0

 

–

1

1

–

–

–

–

2

2

 

Case report 7

67

52

Spt

32

No

  

0

 

–

 

1 + 3

–

–

–

3

3

3

Diverticulitis

Maeda [27]

65

*50*

Spt

–

34

1

0

1

6

–

–

4

< 10

–

6

6

–

3

 

Manero [28]

62

47

Spt

–

No

  

0

 

–

–

1

–

0

–

–

2

2

 

Matsushima [29]

56

50

Spt

31

No

  

0

 

–

1

3

12.6

48

–

6

6

2

 

Rose e Silva 1 [30]

62

48

Spt

–

–

  

0

 

–

–

1

–

8

–

–

2

2

 

Rose e Silva 1 [30]

78

58

Spt

–

58

1

0

0

 

–

–

0

–

6

6

–

6

5

 

Rose e Silva 1 [30]

54

48

Spt

–

–

  

0

 

–

–

1

–

30

–

–

3

3

Hypertension

Medina [31]

74

54

Spt

29

No

  

0

  

1

1

–

0

–

–

6

3

 

Bellina [32]

54

47

Surg

–

47

1

0

0

 

–

–

5

25

–

–

–

6

2

 

Izuishi [33]

54

52

Spt

–

No

  

0

 

–

–

1

–

Normal

6

–

–

3

 

Popoutchi [34]

74

52

Spt

–

71

2

0

0

 

–

–

3

–

–

6

–

–

3

Obesity

Torres-Rincón [35]

49

*50*

–

–

No

  

–

  

–

5

–

–

–

–

–

–

 

Deval [36]

69

*50*

Spt

32

No

  

0

 

1

1

1 + 3

–

0

–

6

6

3

 

Bidarmaghz [37]

63

49

Spt

–

No

  

0

   

5

–

–

6

–

–

3

 

Gudla [38]

63

48

Surg

–

48

2

0

0

 

–

1

5

–

19

6

–

–

3

 

Bailey [39]

53

45

Surg

37

45

2

3

0

 

–

–

0

16

–

6

6

–

3

Hypertension, obesity

Khong [40]

62

50

Surg

–

50

2

2 + 5

0

 

–

–

4

–

–

–

–

3

3

Hypertension

Zhuang [41]

62

*50*

Spt

–

No

  

0

   

4

–

–

6

–

–

3

 

Rabinerson [42]

58

52

Spt

–

43

4

0

0

   

3

–

15

–

–

3

3

 

Jakhmola [43]

50

*48*

Spt

–

No

  

0

 

2

1

1

–

–

6

–

–

4

 

Bhat [44]

50

*48*

Surg

–

?

2

3

0

 

1

1

0

–

596

3

–

–

3

 

Suchonska [45]

84

50

Spt

–

No

  

0

   

4

–

 

6

–

6

3

Hypertension

Agarwal Sharma [46]

69

*50*

Spt

–

No

  

0

 

–

–

5

–

120

6

–

6

2

 

Mohamed [47]

60

*50*

Spt

–

No

  

0

 

1

1

5

–

0

6

–

–

3

 

Plodeck [48]

72

*50*

Spt

–

?

1

0

0

 

2

1

5

–

0

6

–

–

3

Hypertension

Flyckt [49]

59

43

Surg

33

43

2

0

1 + 2

4

–

–

1

19

–

6

–

–

–

 

Cameron [50]

66

50

Surg

 

50

2

0

2

9

  

0

–

–

6

–

–

5

 

Sasson [51]

61

45

Spt

38

59

4

4

2

3

–

1

5

39

7

5

–

5

5

 

Jaegle [52]

62

*50*

Spt

41

No

  

3

43

  

4

–

38

6

–

6

4

Hypertension, diabetes 2, obesity

Bese [53]

74

50

Spt

30

61

5

3

3 + 5

24

 

–

0

–

64

6

–

–

3 + 6

 
  1. Age of menopause (if not mentioned or unknown because of a previous hysterectomy or tamoxifen *50* or *48* are used to calculate time since menopause). Type of menopause: spontaneous or surgical. Type of previous surgery (0, no or not mentioned; 1, hysterectomy; 2, hysterectomy and bilateral adnexectomy; 3, bowel resection; 4, others; 5, subtotal hysterectomy and bilateral salpingo-oophorectomy). Endometriosis during previous surgery (0, no; 1, superficial; 2, cystic ovarian; 3, deep; 4, abdominal wall; 5, adenomyosis). Medical therapy before surgery (0, no; 1, GnRha; 2, aromatase inhibitors; 3, tamoxifen). Indication for investigation: severe pain (1–2–3), increasing pain (1), or cyst (2), finding during clinical exam (0, accidental finding; 1, chronic pain; 2, dyspareunia; 3, bowel symptoms; 4, urinary symptoms; 5, abdominal pain). Final diagnosis (1, typical endo; 2, cystic ovarian endo; 3, deep endo; 4, deep cystic; 5, abdominal wall; 6, malignancy; 7, normal)