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Table 1 Women with progressive endometriosis after menopause in the absence of estrogens

From: Symptomatic endometriosis developing several years after menopause in the absence of increased circulating estrogen concentrations: a systematic review and seven case reports

Patient Age Menopause   BMI, kg/m2 Previous surgery Medication Indication for diagnosis Final diagnosis Comorbidities
Age   Age Type Endo Type Months Pain type Pain increasing Finding E2, pg/ml CA125, U/mL CT MRI US Surgery
Case report 1 72 54 Spt   65 4 0 0   3 1 1 – – –   3 3 Diverticulitis
Case report 2 64 51 Surg 37 51 2 3 0   3 1 1 + 2 + 3 – – – 3 3 3 Diabetes, hypertension, obesity
Case report 3 62 45 Spt 31 57   3 1 3 3 1 1 + 3 – – – 3 3 – Hypertension, obesity
Case report 4 43 36 Spt 24 36 2 3 0   3 1 1 – – – 0 0 3 + 4  
Case report 5 37 32 Spt 27 32 4 3 1 6 3 1 1 – – – 3 3 – Adenomyosis
Case report 6 52 48 Spt – 50 1 5 0   – 1 1 – – – – 2 2  
Case report 7 67 52 Spt 32 No    0   –   1 + 3 – – – 3 3 3 Diverticulitis
Maeda [27] 65 *50* Spt – 34 1 0 1 6 – – 4 < 10 – 6 6 – 3  
Manero [28] 62 47 Spt – No    0   – – 1 – 0 – – 2 2  
Matsushima [29] 56 50 Spt 31 No    0   – 1 3 12.6 48 – 6 6 2  
Rose e Silva 1 [30] 62 48 Spt – –    0   – – 1 – 8 – – 2 2  
Rose e Silva 1 [30] 78 58 Spt – 58 1 0 0   – – 0 – 6 6 – 6 5  
Rose e Silva 1 [30] 54 48 Spt – –    0   – – 1 – 30 – – 3 3 Hypertension
Medina [31] 74 54 Spt 29 No    0    1 1 – 0 – – 6 3  
Bellina [32] 54 47 Surg – 47 1 0 0   – – 5 25 – – – 6 2  
Izuishi [33] 54 52 Spt – No    0   – – 1 – Normal 6 – – 3  
Popoutchi [34] 74 52 Spt – 71 2 0 0   – – 3 – – 6 – – 3 Obesity
Torres-Rincón [35] 49 *50* – – No    –    – 5 – – – – – –  
Deval [36] 69 *50* Spt 32 No    0   1 1 1 + 3 – 0 – 6 6 3  
Bidarmaghz [37] 63 49 Spt – No    0     5 – – 6 – – 3  
Gudla [38] 63 48 Surg – 48 2 0 0   – 1 5 – 19 6 – – 3  
Bailey [39] 53 45 Surg 37 45 2 3 0   – – 0 16 – 6 6 – 3 Hypertension, obesity
Khong [40] 62 50 Surg – 50 2 2 + 5 0   – – 4 – – – – 3 3 Hypertension
Zhuang [41] 62 *50* Spt – No    0     4 – – 6 – – 3  
Rabinerson [42] 58 52 Spt – 43 4 0 0     3 – 15 – – 3 3  
Jakhmola [43] 50 *48* Spt – No    0   2 1 1 – – 6 – – 4  
Bhat [44] 50 *48* Surg – ? 2 3 0   1 1 0 – 596 3 – – 3  
Suchonska [45] 84 50 Spt – No    0     4 –   6 – 6 3 Hypertension
Agarwal Sharma [46] 69 *50* Spt – No    0   – – 5 – 120 6 – 6 2  
Mohamed [47] 60 *50* Spt – No    0   1 1 5 – 0 6 – – 3  
Plodeck [48] 72 *50* Spt – ? 1 0 0   2 1 5 – 0 6 – – 3 Hypertension
Flyckt [49] 59 43 Surg 33 43 2 0 1 + 2 4 – – 1 19 – 6 – – –  
Cameron [50] 66 50 Surg   50 2 0 2 9    0 – – 6 – – 5  
Sasson [51] 61 45 Spt 38 59 4 4 2 3 – 1 5 39 7 5 – 5 5  
Jaegle [52] 62 *50* Spt 41 No    3 43    4 – 38 6 – 6 4 Hypertension, diabetes 2, obesity
Bese [53] 74 50 Spt 30 61 5 3 3 + 5 24   – 0 – 64 6 – – 3 + 6  
  1. Age of menopause (if not mentioned or unknown because of a previous hysterectomy or tamoxifen *50* or *48* are used to calculate time since menopause). Type of menopause: spontaneous or surgical. Type of previous surgery (0, no or not mentioned; 1, hysterectomy; 2, hysterectomy and bilateral adnexectomy; 3, bowel resection; 4, others; 5, subtotal hysterectomy and bilateral salpingo-oophorectomy). Endometriosis during previous surgery (0, no; 1, superficial; 2, cystic ovarian; 3, deep; 4, abdominal wall; 5, adenomyosis). Medical therapy before surgery (0, no; 1, GnRha; 2, aromatase inhibitors; 3, tamoxifen). Indication for investigation: severe pain (1–2–3), increasing pain (1), or cyst (2), finding during clinical exam (0, accidental finding; 1, chronic pain; 2, dyspareunia; 3, bowel symptoms; 4, urinary symptoms; 5, abdominal pain). Final diagnosis (1, typical endo; 2, cystic ovarian endo; 3, deep endo; 4, deep cystic; 5, abdominal wall; 6, malignancy; 7, normal)
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