Postpartum transcervical endometrial resection under laparoscopic control for retained degenerated products of conception
© Springer-Verlag Berlin / Heidelberg 2005
Received: 21 December 2004
Accepted: 15 March 2005
Published: 25 May 2005
We describe a case of postpartum haemorrhage due to retained products of conception that failed to resolve after two attempts of evacuation of retained products of conception. A subsequent histology and MRI scan confirmed retained products of conception despite repeated attempts at treatment. We introduce transcervical endometrial resection as an efficient method of removing degenerated retained products of conception refractory to standard treatment.
Secondary postpartum haemorrhage is defined as any sudden loss of blood (regardless of volume) from the genital tract occurring after the first 24 h postpartum and within 6 weeks of delivery. The incidence is between 0.5 and 1.5% . The most common causes are retained products of conception and/or infection . Standard treatment is with antibiotics and/or evacuation of retained products of conception (ERPC). Our case highlights the use of endometrial resection as an effective means for removing postpartum products of conception refractory to standard treatment.
A 30-year-old Caucasian woman in her second pregnancy had an elective caesarean section done at 39 weeks gestation, the indication being previous caesarean section and lower back pain. This back pain was due to L5/S1 disc prolapse and intermittent right sciatica. The operation was uncomplicated; however, the placenta was removed manually after an unsuccessful attempt at continuous cord traction. Following delivery, inspection of the placenta confirmed it was complete.
She remained well until the fourth week postpartum when she started bleeding per vaginum. Bleeding had been ongoing for five days prior to her presentation in the hospital. The bleeding was heavy with passage of clots. There was associated crampy lower abdominal pain.
She was admitted six weeks later with a history of continuous bleeding per vaginum with intermittent exacerbations that had not stopped since the evacuation. The ultrasound scan showed that the fundal endometrium was thickened and heterogenous over an area of 4.4×4.1×3.9 cm.
She subsequently had another evacuation of retained products of conception under ultrasound control. Hard tissue was removed from the uterus resembling fibroid tissue. However, no tissue resembling products of conception was recovered. A hysteroscopy was therefore performed following the ERPC, confirming an appearance suggestive of submucous fibroid. This could not be removed with polyp forceps as it was densely adherent to the endometrial cavity.
She was discharged on oral antibiotics for one week and also prescribed Zoladex injection 3.6 mg subcutaneously monthly for three cycles with the aim of shrinking the submucus fibroid mass.
She was admitted five days later with colicky lower abdominal pain. Conservative management was done with analgesics while the histology report was fast-tracked. The report showed fragments of necrotic degenerative and calcified chorionic villi and deciduas with no evidence of fibroid.
The history of heavy bleeding four weeks postpartum, along with the clinical and ultrasound findings, suggested that our patient had secondary postpartum haemorrhage due to retained placental tissue. Intravenous antibiotics were given and an evacuation was done. Retained placental tissue is commonly infected, so intravenous broad spectrum antibiotics should ideally be given prior to evacuation considering it takes an hour for antibiotic levels to peak in the circulation . Hoveyda et al  found that 63% of cases of secondary postpartum haemorrhage required a surgical evacuation, and 37% had retained placental tissue confirmed after surgery. In our patient the histology confirmed trophoblast tissue.
She continued to bleed and required another evacuation procedure six weeks later followed by hysteroscopy. The image and texture during the operation suggested a submucous fibroid. However, the histology showed fragments of necrotic degenerative and calcified chorionic villi and deciduas. An MRI scan also suggested retained products of conception. The possibility of a placenta accreta was also entertained, but this was ruled out by the histology and MRI.
An injection of Zoladex 3.6 mg subcutaneous was given to the patient, as it has been suggested that Zoladex induces endometrial thinning, reducing operating time and improving the intrauterine operating environment during endometrial ablation . In our study it softened the texture of the retained trophoblastic tissue.
Four weeks later, a hysteroscopic endometrial resection of the retained products of conception was performed under laparoscopic control. We believe that this is the first time that endometrial resection has been done for retained products of conception. Quen et al  described a similar technique of transcervical endometrial resection for placenta increta. Our case suggests the effectiveness of this technique in dealing with postpartum degenerated calcified retained products of conception that are refractory to the standard management of ERPC.
- Thomson W, Ann Harper M (2001) Postpartum haemorrhage and abnormalities of the third stage of labour. In: Chamberlain G, Steer PJ (eds) Turnbull’s obstetrics, 3rd edn. Harcourt, London, pp 619–633Google Scholar
- Dewhurst CJ (1966) Secondary postpartum haemorrhage. J Obstet Gynaecol Br Commonwealth 73:53–58Google Scholar
- Neill A, Thornton S (2002) Secondary postpartum haemorrhage. J Obstet Gynaecol 3:119–122View ArticleGoogle Scholar
- Hoveyda F, Mackenzie IZ (2001) Secondary postpartum haemorrhage: incidence, morbidity and current management. BJOG 108:927–930View ArticlePubMedGoogle Scholar
- Sowter MC, Lethaby A, Singla AA (2002) Pre-operative endometrial thinning agents before endometrial destruction for heavy menstrual bleeding. Cochrane Database Syst Rev 3:CD001124PubMedGoogle Scholar
- Quan S, Li FF, Fan JM, Gao YF, Yu YH (2002) Trancervical endometrial resection under hysteroscopy for placenta increta: report of one case. Di Yi Jun Da Xue Bao 22:471Google Scholar