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Table 2 Primary systemic MTX treatment of interstitial pregnancy

From: Elective uterine artery embolization prior to laparoscopic resection of interstitial pregnancy: two cases and literature review

Author N Initial β-hCG Systemic MTX treatment Hospital stay Negative β-hCG Success
Jermy et al. [24] 17 32–31,381 50 mg/m2 IM 0–40 3–13 16/17
Hiersch et al. [25] 14 15,764 1 mg/kg/d IM on day 1, 3, 5, 7 N/A N/A 9/14
  3 < 2500 50 mg/m2 IM 1 N/A 3/3
Tanaka et al. [26] 33 230–106,634 100 mg IV + 200 mg IV 1–4 3–19 31/33
Kim et al. [12] 5 375–102,970 1 mg/kg/d IM on day 1, 3, 5, 7 N/A N/A 14/30
  24   50 mg/m2 IM N/A N/A  
  1   100 mg IV in bolus followed by 200 mg IV N/A N/A  
  1. N number of cases, β-hCG mIU/ml, MTX methotrexate, IM intramuscular, IV intravenous, hospital stay days, negative β-hCG weeks