Indications of diagnostic hysteroscopy, a brief review of the literature

AUB is probably the most common abnormal condition in gynecological practice especially for women over the age of 45 years old. It also affects almost 25% of reproductive aged women. Plenty of diagnostic techniques (such as TVS, TVS with saline solution infusion, D&C, and endometrial biopsy) have been widely used in order to evaluate women with AUB. In recent years, hysteroscopy has been widely used as an outpatient office procedure in combination with direct biopsy after visualization of the endometrial cavity. Plenty of authors till today have managed to demonstrate the great potential of hysteroscopy as the gold standard method for the investigation of women with such pathology. Barati et al. have announced that in a sum of 147 women with AUB and normal TVS, 32 of them (21.8%) were hysteroscopically abnormal, and cervical canal polyp has been described as the commonest lesion that has been misdiagnosed by TVS [1]. Endometrial or cervical polyps can be treated better by hysteroscopy since D&C has proved to be less effective [2]. A few years earlier, Refaie et al. evaluated 112 pre- and postmenopausal women with AUB in order to assess if an outpatient hysteroscopy affects the decision making of treatment. The authors concluded that half of the women had abnormal uterine cavities with most common findings the submucous myomas and endometrial polyps and that hysteroscopical investigation of AUB could lead to the most appropriate treatment, without unnecessary major surgical intervention [3]. Bettocchi et al. have proved the efficacy of office hysteroscopy treatment in benign intrauterine pathologies in menopausal women. He has enrolled in his study a sum of 925 menopausal women with AUB in a period of 5 years and divided them into two investigation groups according to the endometrial thickness (group 1 <4 mm, group 2 >4 mm). The conclusion was that the diagnostic value of hysteroscopy yielded 99–100% specificity and sensitivity respectively for both groups [4]. In an attempt of some authors to summarize the results of diagnostic hysteroscopy, a systematic review has been published by H Van Dongen et al. In this study, 17 articles in a meta-analysis have been enrolled and it has been proposed that diagnostic hysteroscopy for women with AUB is both accurate and feasible in the detection of intrauterine anomalies with a success rate estimated approximately at 96.9% (SD 5.2%, range 83–100%) [5].

Summarizing, we can assume that the most frequent hysteroscopic findings in patients with AUB are the submucous myomas, polyps, and endometrial hyperplasia, either benign or malignant, in about 60–70% of the cases. Moreover, diagnostic hysteroscopy as a method is even more valuable and with greater success rates, in the identification of AUB in perimenopausal and postmenopausal women with no specific risk of cancer progression.

The most common type of pelvic malignancy still remains the endometrial cancer. This type of malignancy causes abnormal genital bleeding usually as a first symptom in most of the cases, thus, the early investigation of such symptom is of great importance for woman's survival and progress. Unfortunately, some of women with endometrial adenocarcinoma remain asymptomatic. Endometrial hyperplasia is deemed as a precursor of endometrial cancer. The most important sign of endometrial cancer or endometrial hyperplasia is the endometrial thickness in an ultrasound exam. Unfortunately, ultrasound exam has very low specificity in the differentiation of the type of endometrial hyperplasia as soon as directed biopsy of the suspected uterus still remains a prerequisite for an appropriate control. An endometrial thickness greater than 4 mm requires further evaluation in postmenopausal women with AUB [6–8]. Hysteroscopy not only can clearly and accurately display the appearance of endometrial cancer but also demonstrates any possible involvement of the lower uterine segment and cervix. Cordeiro and her colleagues summarized hysteroscopic findings in 245 postmenopausal women with increased endometrial thickness in TVS and compared the diagnostic outcomes regarding the presence or absence of AUB [9]. In this study, the investigators suggested that sensitivity, specificity, positive predictive, and negative predictive value of hysteroscopy for endometrial carcinoma was 94.1%, 98.95%, 88.9%, and 99.5%, respectively. Also, the concordance between hysteroscopic findings and histological diagnosis was 89.9%. The specificity and negative predictive value of hysteroscopy for diagnosing cancer were similar to other authors [10].

In all this continuing debate about the value and the accuracy of hysteroscopy in the diagnosis of serious endometrial disease (cancer and hyperplasia), plenty of answers have been given by a systematic quantitative review that has been announced by JT Clark and co partners. In this review, 65 papers have been isolated and the results were the following: The overall sensitivity and specificity of hysteroscopy for endometrial cancer was 86.4% and 99.2%, respectively. The variation in sensitivity was much greater than the variation in specificity of diagnostic hysteroscopy in endometrial disease (cancer and hyperplasia), and finally concluded that as a method, diagnostic hysteroscopy is safe with low incidence of serious complications, with high accuracy in diagnosing endometrial cancer rather than excluding it, and with high accuracy in diagnosing endometrial disease (cancer and hyperplasia) mainly in postmenopausal women rather than in premenopausal [11].

Another great debate enrolls the hypothesis of dissemination of cancer cells after diagnostic hysteroscopy in women with endometrial cancer. Some investigators have proposed that distention of the endometrial cavity with saline solution or CO₂ during the hysteroscopic procedure can, under certain circumstances, disseminate endometrial cancer cells to the abdominal cavity and change both the prognosis and the course of treatment. There are several conflicted arguments and concerns about this hypothesis. On the one hand, it is well-known that all examination methods (bimanual examination, D&C, and even hysterectomy) may lead to migration of endometrial cancer cells through the fallopian tubes to systemic circulation and peritoneal cavity without increasing the incidence of metastasis. Tanizawa et al. in 1,040 women with endometrial cancer examined by hysteroscopy, found no significant differences in the presence of intraperitoneal tumor cells compared to patients evaluated by a different method [12]. Taddei et al. demonstrated that hysteroscopy evaluation of the extent of endometrial carcinoma could lead to an individualized therapeutic program and have a beneficial effect on survival rates [13]. Nagele et al. in a prospective randomized self-controlled study showed that there was no significant difference in the spreading of endometrial cells after hysteroscopy either by the use of natural solution or by the use of CO₂ for uterine distention. Only transtubal dissemination has occurred in about 25% of the patients [14]. Finally, de Sousa Damiao et al., after they have diagnosed endometrial cancer in 72 women, concluded that the hysteroscopic evaluation of endometrial cancer, if it is performed under low pressure of CO₂, does not cause spread of malignant endometrial cells into the peritoneal cavity [15]. On the other hand, Takac et al., after a retrospective study on 146 patients with endometrial cancer, emphasized that hysteroscopy significantly increases the risk of positive peritoneal cytology in women with endometrial cancer in comparison with D&C [16]. Revel et al. only a few years earlier have mentioned an increased risk of peritoneal contamination by malignant cells after hysteroscopy but with no evidence for these women to face worse prognosis comparing to patients who have undergone other diagnostic procedures [17]. Polyzos and his colleagues very recently analyzed nine clinical trials with 1,015 women with histologically proven endometrial carcinoma who either underwent or not preoperative hysteroscopy evaluation. Hysteroscopy resulted in a significantly higher rate of malignant peritoneal cytology compared to no hysteroscopy, especially if the distention medium was isotonic sodium chloride and if the inflated media pressure reached or exceeded 100 mmHg [18].

According to the WHO guidelines, HSG is recommended to all infertile women in order to be evaluated properly for the uterine malformations that are responsible for infertility problems [20]. The goal of uterine cavity evaluation is to detect uterine malformations such as polyps, myomas, or uterine septums that can negatively influence the embryo implantation [21]. There is an ongoing debate regarding the value of routine hysteroscopy before an in vitro fertilisation (IVF) attempt. Hysteroscopic examination seems to be superior in the evaluation of these patients than HSG [21]. Barati et al. have enrolled in a study women with unexplained infertility and women with infertility because of uterine factor. He investigated them either by TVS and HSG, or by TVS, HSG, and hysteroscopy. There was a 38.8% positive finding in office hysteroscopy despite of normal TVS and HSG. He concluded that office hysteroscopy should be a part of routine work in the evaluation of infertile women [22]. Kumar and his colleagues compared the diagnostic efficacy of HSG and hysteroscopy in assessment of uterine factor in infertile women in a 2-year study in which 60 patients were subjected to HSG and hysteroscopy as well. They have showed specificity of HSG as 90% and false negative value as 40%. They have mentioned the significant role of HSG as a screening procedure but it must be supplemented by hysteroscopy although it is an observer-dependent technique [23]. Koskas et al. evaluated hysteroscopically 556 women with difficulty to conceive after 1 year of unprotected intercourse and found that first-line office hysteroscopy for infertility showed abnormal findings which ranged from 30% at women 30 years old to more than 60% at women more than 42 years old. Thus, they have proposed an additional argument that office hysteroscopy must be part of first-line exams in infertile women regardless of age [24]. Very recently, Bosteels et al. revealed a systemic review about the effectiveness of hysteroscopy in subfertile women without other gynecological symptoms. The investigators detected that removal of endometrial polyps doubles the pregnancy rate compared with diagnostic hysteroscopy and polyp biopsy in women who undergo IUI. They also mentioned the lack of randomized controlled trials on hysteroscopic treatment of intrauterine adhesions and also that diagnostic hysteroscopy in the cycle preceding subsequent IVF attempt almost doubles the pregnancy rates in women with at least two failed IVF attempts in comparison with women starting IVF immediately [25]. In order to reveal the impact of hysteroscopy in patients with two or more failed IVF cycles, El-Toukhy et al. have announced a systemic review and meta-analysis in 2008 in which 1,691 women divided into two groups participated; one of hysteroscopy and one control group. According to the authors, there was a remarkable evidence of benefit from hysteroscopy in increasing the chance of pregnancy in a subsequent IVF cycle [26].